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CD49b (Integrin alpha 2) Monoclonal Antibody (eBioY418 (Y418)), FITC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£69.50 - £163.00
Specifications
Antigen | CD49b (Integrin alpha 2) |
---|---|
Clone | eBioY418 (Y418) |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15556416
|
Affymetrix eBioscience
11-0498-42 |
100 Tests |
£163.00
100 tests |
Estimated Shipment: 24-05-2024 Log in to see stock. |
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15546416
|
Affymetrix eBioscience
11-0498-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The eBioY418 (Y418) monoclonal antibody reacts with human CD49b, the 150-kDa, integrin alpha 2 subunit. The complex of CD49b non-covalently associated with integrin beta 1 (CD29), also known as VLA-2, is a receptor for collagen and laminin. This complex is expressed by lymphocytes, activated T cells, monocytes and platelets. Applications Reported: This eBioY418 (Y418) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioY418 (Y418) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.Specifications
CD49b (Integrin alpha 2) | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P17301 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
eBioY418 (Y418) | |
Flow Cytometry | |
FITC | |
Mouse | |
Human | |
3673 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |
For Research Use Only.