CD47 Mouse anti-Human, Clone: B6H12, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0479-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15298457

Quantity Price
1 £ 219.5 / 500µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Format Purified
Species Reactivity Human
Conjugate Unlabeled
Gene Alias Integrin associated protein, IAP
Isotype IgG1
Formulation aqueous buffer, no sodium azide
Storage Requirements Store at 2-8°C.
Clone B6H12
Concentration 1mg/mL
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Functional Assay
Antigen CD47
Primary or Secondary Primary
Quantity 500μg
Regulatory Status RUO

The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 integrins CD51/CD61 and CD41/CD61. Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells.

This antibody has been reported to have neutralizing activity.