CD47 Mouse anti-Human, APC, Clone: B6H12, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0479-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15597936

Quantity Price
1 £ 192.42000000000002 / 100 tests
EU Stock 12
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Description and Specification

Specification

Quantity 100 Tests
Host Species Murine
Conjugate Allophycocyanin
Antigen CD47
Applications Flow Cytometry
Isotype IgG1
Clone B6H12
Gene Alias Integrin associated protein, IAP
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Primary or Secondary Primary
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (1μg)/test
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody B6H12 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 integrins CD51/CD61 and CD41/CD61. Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells.

This antibody has been reported to have neutralizing activity.