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CD45RO Monoclonal Antibody (UCHL1), PE-Cyanine5, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£79.50 - £194.00

Specifications

Antigen CD45RO
Clone UCHL1
Applications Flow Cytometry
Classification Monoclonal
Conjugate PE-Cyanine5
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15597726
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Affymetrix eBioscience
15-0457-42
100 Tests
£194.00
100 tests
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15587726
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Affymetrix eBioscience
15-0457-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

CD45RO is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Specifications

Specifications

CD45RO
Flow Cytometry
PE-Cyanine5
Mouse
Human
5788
IgG2a κ
Affinity chromatography
PTPRC
UCHL1
Monoclonal
Liquid
RUO
P08575
PTPRC
Primary
Antibody
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Documents

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