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CD45RO Monoclonal Antibody (UCHL1), PE-Cyanine5, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£79.50 - £194.00
Specifications
Antigen | CD45RO |
---|---|
Clone | UCHL1 |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugate | PE-Cyanine5 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15597726
|
Affymetrix eBioscience
15-0457-42 |
100 Tests |
£194.00
100 tests |
Estimated Shipment: 10-04-2024 Log in to see stock. |
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15587726
|
Affymetrix eBioscience
15-0457-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
CD45RO is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.Specifications
CD45RO | |
Flow Cytometry | |
PE-Cyanine5 | |
Mouse | |
Human | |
5788 | |
IgG2a κ | |
Affinity chromatography | |
PTPRC |
UCHL1 | |
Monoclonal | |
Liquid | |
RUO | |
P08575 | |
PTPRC | |
Primary | |
Antibody |
For Research Use Only.