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CD42b Mouse anti-Human, APC, Clone: HIP1, eBioscience™

Mouse Monoclonal Antibody

£72.50 - £183.00

Specifications

Antigen CD42b
Clone HIP1
Target Species Human
Conjugate APC
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15507936
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Affymetrix eBioscience
17-0429-42
100 Tests £183.00
100 tests View alternative products
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Estimated Shipment
04-11-2020
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15597926
View Documents
Affymetrix eBioscience
17-0429-41
25 Tests £72.50
25 tests View alternative products
Save Up to 
»
Estimated Shipment
01-12-2020
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Description

Description

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Specifications

Specifications

CD42b
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
HIP1
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.