CD42a Mouse anti-Human, eFluor 450, Clone: GR-P, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-0428-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15569676

Quantity Price
1 £ 136.82 / 100 tests
EU Stock 4
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Description and Specification

Specification

Host Species Murine
Quantity 100 Tests
Conjugate eFluor 450
Concentration 5μL (0.25μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Antigen CD42a
Isotype IgG1
Format Conjugated
Clone GR-P
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Glycoprotein IX, GP9
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Applications Flow Cytometry
Species Reactivity Human

This GR-P monoclonal antibody reacts with human CD42a, which is also known as glycoprotein IX (GPIX). CD42a is a 22kDa transmembrane protein that is constitutively expressed on platelets and megakaryocytes. CD42a associates with CD42b, CD42c, and CD42d to form the GPIb-V-IX complex, which binds the von Willebrand factor, an endothelial adhesion protein, to mediate platelet adhesion and activation. This binding results in platelet aggregation at sites of vascular injury. This receptor complex has also been demonstrated to bind thrombin, factors XI and XII, P-selectin, and Mac-1. Finally, a point mutation within the leucine-rich motif of CD42a has been linked to Bernard-Soulier syndrome.