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CD41 Rat anti-Mouse, Biotin, Clone: eBioMWReg30 (MWReg30), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0411-81

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15249549

  • £48.89 / 50µg


Estimated Shipment date
from Supplier 26-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.
Specifications

Specifications

CD41
eBioMWReg30 (MWReg30)
Biotin
Conjugated
Rat
50μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib
IgG1
RUO
Primary
Murine