CD40 Rat anti-Mouse, PE-Cy5, Clone: 1C10, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 15-0401-81
UNSPSC : 12352200
Code : Z2
Additional Details : Weight : 0.25000kg
DescriptionThe 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.
The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|