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CD40 Rat anti-Mouse, Clone: 1C10, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-0401-86

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15288437

  • £335.66 / 1mg


EU Stock 3
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Disclaimers:

For Research Use Only.


Specifications

Description

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.
Description & Specifications

Specifications

CD40
1C10
Unlabeled
aqueous buffer, no sodium azide
Rat
1mg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
Purified
TNFRSF5
IgG2a
RUO
Primary
Murine