CD40 Rat anti-Mouse, Clone: 1C10, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0401-86

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288437

Quantity Price
1 £ 335.65999999999997 / 1mg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Format Purified
Conjugate Unlabeled
Formulation aqueous buffer, no sodium azide
Storage Requirements Store at 2-8°C.
Quantity 1mg
Clone 1C10
Species Reactivity Mouse
Regulatory Status RUO
Isotype IgG2a
Gene Alias TNFRSF5
Primary or Secondary Primary
Host Species Rat
Antigen CD40
Concentration 1mg/mL
Monoclonal or Polyclonal Monoclonal

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.