CD40 Rat anti-Mouse, Clone: 1C10, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0401-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268437

Quantity Price
1 £ 97.22 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Species Reactivity Mouse
Host Species Rat
Isotype IgG2a
Clone 1C10
Gene Alias TNFRSF5
Antigen CD40
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Applications Flow Cytometry
Applications Functional Assay
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Concentration 1mg/mL
Regulatory Status RUO
Quantity 100μg
Primary or Secondary Primary

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.