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CD40 Rat anti-Mouse, Clone: 1C10, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-0401-81

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258437

  • £48.31 / 50µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Description

Description

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.
Specifications

Specifications

CD40
1C10
Unconjugated
Purified
Rat
50μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
TNFRSF5
IgG2a
RUO
Primary
Murine
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