CD40 Rat anti-Mouse, APC, Clone: 1C10, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0401-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15370600

Quantity Price
1 £ 111.78 / 50µg
EU Stock 2
Add to basket


Description and Specification

Specification

Host Species Rat
Isotype IgG2a
Applications Flow Cytometry
Conjugate APC
Antigen CD40
Quantity 50μg
Regulatory Status RUO
Format Conjugated
Primary or Secondary Primary
Species Reactivity Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 1C10
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias TNFRSF5
Monoclonal or Polyclonal Monoclonal
Concentration 0.2mg/mL

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The monoclonal antibody 1C10 is reported to have agonistic activity in vitro and in vivo.