missing translation for 'onlineSavingsMsg'
Learn More

CD40 Monoclonal Antibody (HI40a), FITC, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen A15747

Code : NEW

Additional Details : Weight : 0.00280kg

Product Code. 15215834

This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.


Description

Description

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin′s disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Specifications

Specifications

CD40
Monoclonal
FITC
CD40
Bp50, CDW40, MGC9013, TNFRSF5, p50
Mouse
Purified
RUO
958
4° C
Liquid
Flow Cytometry
HI40a
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
P25942
CD40
Human CD40
100 Tests
Primary
Human
Antibody
IgG1
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers