CD40 Mouse anti-Human, eFluor 450, Clone: 5C3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-0409-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15519676

Quantity Price
1 £ 66.65 / 25 tests
Estimated Shipment date
from Supplier 04-04-2017
Add to basket


Description and Specification

Specification

Applications Flow Cytometry
Gene Alias TNFRSF5
Antigen CD40
Primary or Secondary Primary
Isotype IgG1
Regulatory Status RUO
Conjugate eFluor 450
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 5C3
Species Reactivity Human
Format Conjugated
Quantity 25 tests
Concentration 5μL (0.125μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal

The 5C3 monoclonal antibody reacts with human CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development and maturation by inducing Ig isotype-switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation. 5C3 is reported to be used for activation of B cells in in vitro functional assays.