CD40 Mouse anti-Human, eFluor 450, Clone: 5C3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-0409-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15529676

Quantity Price
1 £ 170.59 / 100 tests
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Primary or Secondary Primary
Applications Flow Cytometry
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD40
Isotype IgG1
Quantity 100 tests
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Gene Alias TNFRSF5
Concentration 5μL (0.125μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Host Species Mouse
Conjugate eFluor 450
Clone 5C3

The 5C3 monoclonal antibody reacts with human CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development and maturation by inducing Ig isotype-switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation. 5C3 is reported to be used for activation of B cells in in vitro functional assays.