CD40 Mouse anti-Human, Clone: 5C3, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0409-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15238447

Quantity Price
1 £ 66.65 / 50µg
EU Stock 1
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Description and Specification

Specification

Regulatory Status RUO
Applications Flow Cytometry
Applications Functional Assay
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Species Reactivity Human
Clone 5C3
Gene Alias TNFRSF5
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Format Purified
Concentration 1mg/mL
Antigen CD40
Isotype IgG1
Conjugate Unlabeled
Formulation aqueous buffer, no sodium azide
Quantity 50μg

The 5C3 monoclonal antibody reacts with human CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development and maturation by inducing Ig isotype-switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation. 5C3 is reported to be used for activation of B cells in in vitro functional assays.