missing translation for 'onlineSavingsMsg'
Learn More

CD40, Functional Grade, clone: HM40-3, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-0402-81

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15298437

  • £62.24 / 50µg


EU Stock 1
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

Description: The HM40-3 monoclonal antibody reacts with mouse and rat CD40, a 45-50kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.Applications Reported: The HM40-3 antibody has been reported for use in flow cytometric analysis. HM40-3 has also been reported in inhibition of binding of soluble CD154 to CD40 and in vitro activation of B cells.Applications Tested: The HM40-3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

CD40
HM40-3
Unconjugated
Purified
Armenian Hamster
50μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
TNFRSF5
IgM
RUO
Primary
Rat
Videos