missing translation for 'onlineSavingsMsg'
Learn More

CD4 Monoclonal Antibody (OX35), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£47.88 - £96.50

Specifications

Antigen CD4
Clone OX35
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Frozen)
Classification Monoclonal
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15236747
View Documents Promotion Details
Affymetrix eBioscience
14-0040-82
100 μg
£96.50
100µg
View alternative products
Save Up to 
»
Estimated Shipment: 07-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
15226747
View Documents Promotion Details
Affymetrix eBioscience
14-0040-81
50 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A View alternative products
Save Up to 
»
Description

Description

Description: The OX35 monoclonal antibody reacts with rat CD4. CD4 is a co-receptor which participates in signaling through the T cell receptor by making contacts with MHC class II expressed on antigen-presenting cells (APC). CD4 is expressed in the thymus by CD4+CD8+ "e;double-positive"e; and CD4+ "e;single-positive"e; thymocytes, and by CD4+ "e;helper"e; T cells in the periphery. CD4 is a cell-surface membrane glycoprotein which contains four extracellular immunoglobulin-like domains. Applications Reported: This OX35 antibody has been reported for use in flow cytometric analysis, and immunohistology staining of frozen tissue sections. Applications Tested: This OX35 antibody has been tested by flow cytometric analysis of rat splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Specifications

Specifications

CD4
0.5 mg/mL
Monoclonal
Liquid
RUO
P05540
IgG2a κ
Affinity chromatography
Antibody
OX35
Flow Cytometry, Immunohistochemistry (Frozen)
Unconjugated
Mouse
Rat
24932
Primary
4° C
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.