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CD39 Mouse anti-Human, Clone: eBioA1 (A1), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0399-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15296927

  • £54.42 / 25µg


Estimated Shipment
29-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBioA1 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) or NTPDase. CD39 is an integral membrane protein with two transmembrane domains and exists as a homotetramer. It is the most prominent ectoenzyme of the immune system. The function of CD39 is to effectively remove toxic extracellular ATP by converting it to ADP or AMP. CD39 is thought to work together with CD73 to hydrolyze ATP and has been well characterized on Langerhans cells. Expression of CD39 was originally identified on activated lymphocytes. Expression is also found on a subset of T cells, B cells and dendritic cells as well as weak staining on monocytes and granulocytes.

Recently, CD39 and CD73 have been found on regulatory T cells (Treg). Expression of CD39 on Treg may facilitate their entry into inflamed areas where high levels of ATP are present. Expression of CD39 on Foxp3+CD4+ cells ranges from 25-45%.
Specifications

Specifications

CD39
eBioA1 (A1)
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Ectonucleoside Triphosphate Diphosphohydrolase 1, Entpd1
IgG1
RUO
Primary
Human