CD38 Mouse anti-Human, PE-Cy7, Clone: HB7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 25-0388-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15548396

Quantity Price
1 £ 180.2 / 100 tests
EU Stock 8
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Clone HB7
Regulatory Status RUO
Isotype IgG1
Gene Alias ADP-Ribosyl Cyclase, Cyclic ADP-Ribose Hydrolase
Quantity 100 tests
Species Reactivity Human
Primary or Secondary Primary
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Conjugate PE-Cy7
Antigen CD38
Concentration 5μL (0.125μg)/test
Format Conjugated
Host Species Mouse

The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45kDa type II transmembrane protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR), both of which are secondary messengers. Expression of CD38 is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. Additionally CD38 is found in a variety of tissues and other hematopoietic cells (e.g. T cells, NK cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony forming cells). In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring calcium levels.