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CD370 (Clec9A) Rat anti-Mouse, PerCP-eFluor 710, Clone: 42D2, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-5975-82

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15351380

  • £195.53 / 100µg


Estimated Shipment
30-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This 42D2 monoclonal antibody reacts with mouse CD370, which is also known as DNGR-1 or Clec9A. CD370 is a C-type lectin-like receptor expressed on conventional and plasmacytoid dendritic cells (DCs). In particular, CD8+ conventional DCs in the thymus, spleen, and lymph nodes, as well as CD24+ DCs in the blood, express CD370. This receptor is not detectable on most B cells, T and NK cells, monocytes, and macrophages. The cytoplasmic domain of CD370 contains an ITAM motif that has been demonstrated to phosphorylate Syk tyrosine kinase, leading to NFAT activation. This signaling reportedly mediates the presentation of necrotic cell-associated antigens by CD8+ DCs in innate immunity.
Specifications

Specifications

CD370 (Clec9A)
42D2
PerCP-eFluor™ 710
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
DNGR-1
IgG1
RUO
Primary
Murine