CD370 (Clec9A) Rat anti-Mouse, PerCP-eFluor 710, Clone: 42D2, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-5975-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15351380

Quantity Price
1 £ 195.53 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Host Species Rat
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 42D2
Quantity 100μg
Applications Flow Cytometry
Format Conjugated
Isotype IgG1
Species Reactivity Mouse
Regulatory Status RUO
Antigen CD370 (Clec9A)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Conjugate PerCP-eFluor 710
Concentration 0.2mg/mL
Gene Alias DNGR-1
Primary or Secondary Primary

This 42D2 monoclonal antibody reacts with mouse CD370, which is also known as DNGR-1 or Clec9A. CD370 is a C-type lectin-like receptor expressed on conventional and plasmacytoid dendritic cells (DCs). In particular, CD8+ conventional DCs in the thymus, spleen, and lymph nodes, as well as CD24+ DCs in the blood, express CD370. This receptor is not detectable on most B cells, T and NK cells, monocytes, and macrophages. The cytoplasmic domain of CD370 contains an ITAM motif that has been demonstrated to phosphorylate Syk tyrosine kinase, leading to NFAT activation. This signaling reportedly mediates the presentation of necrotic cell-associated antigens by CD8+ DCs in innate immunity.