CD370 (Clec9A) Rat anti-Mouse, PE, Clone: 42D2, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5975-82

UNSPSC: 12352203

Code: Z1

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 13406853

Quantity Price
1 £ 170.59 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Quantity 100μg
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Isotype IgG1
Conjugate PE
Concentration 0.2mg/mL
Format Conjugated
Species Reactivity Mouse
Host Species Rat
Antigen CD370 (Clec9A)
Gene Alias DNGR-1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Clone 42D2
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal

This 42D2 monoclonal antibody reacts with mouse CD370, which is also known as DNGR-1 or Clec9A. CD370 is a C-type lectin-like receptor expressed on conventional and plasmacytoid dendritic cells (DCs). In particular, CD8+ conventional DCs in the thymus, spleen, and lymph nodes, as well as CD24+ DCs in the blood, express CD370. This receptor is not detectable on most B cells, T and NK cells, monocytes, and macrophages. The cytoplasmic domain of CD370 contains an ITAM motif that has been demonstrated to phosphorylate Syk tyrosine kinase, leading to NFAT activation. This signaling reportedly mediates the presentation of necrotic cell-associated antigens by CD8+ DCs in innate immunity.