CD369 (Clec7A, Dectin-1) Mouse anti-Human, Non-human primate, Clone: 15E2, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9856-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15527836

Quantity Price
1 £ 115.56 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, no sodium azide
Format Purified
Host Species Mouse
Isotype IgG2a
Clone 1.50E+03
Monoclonal or Polyclonal Monoclonal
Applications Functional Assay
Gene Alias Beta-glucan receptor, CLEC7A
Quantity 100μg
Antigen CD369 (Clec7A, Dectin-1)
Storage Requirements Store at 2-8°C.
Concentration 1mg/mL
Species Reactivity Human, Non-human primate
Regulatory Status RUO
Primary or Secondary Primary
Conjugate Unlabeled

This 15E2 monoclonal antibody reacts with human and non-human primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation.

The 15E2 monoclonal antibody has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369.