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CD369 (Clec7A, Dectin-1) Mouse anti-Human, Non-human primate, Clone: 15E2, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-9856-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15527836

  • £115.56 / 100µg


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For Research Use Only.


Description

Description

This 15E2 monoclonal antibody reacts with human and non-human primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation.

The 15E2 monoclonal antibody has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369.
Specifications

Specifications

CD369 (Clec7A, Dectin-1)
1.50E+03
Unconjugated
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
Beta-glucan receptor, CLEC7A
IgG2a
RUO
Primary
Non-human Primate
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