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CD366 (TIM3) Monoclonal Antibody (RMT3-23), PE-Cyanine7, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£92.25 - £224.00
Specifications
Antigen | CD366 (TIM3) |
---|---|
Clone | RMT3-23 |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15508586
|
Affymetrix eBioscience
25-5870-80 |
25 μg |
£92.25
25µg |
In Stock Log in to see stock. |
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15518586
|
Affymetrix eBioscience
25-5870-82 |
100 μg |
£224.00
100µg |
Estimated Shipment: 08-04-2024 Log in to see stock. |
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Description
Description: The RMT3-23 monoclonal antibody reacts with mouse CD366 (TIM3), a Th1-specific cell surface protein. The RMT3-23 antibody reacts with CD366 protein expressed by both BALB/c and C57BL/6 strains of mice. CD366, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. CD366 is expressed selectively by differentiated CD4^+Th1 and CD8^+Tc1 cells, but is absent on CD4^+Th2 and CD8^+Tc2 cells. Other hematopoietic cell types, including naive T cells, B cells, macrophages and dendritic cells, do not express CD366, at least at the protein level. CD366 expression is upregulated at a late stage of T cell differentiation on Th1 cells after 3 rounds of in vitro polarization suggesting a role for this molecule in the transport or effector function of Th1 cells rather than a contribution to T cell differentiation. In an experimental autoimmune encephalomyelitis (EAE) model, CD366 was shown to be expressed on most CD4^+ and CD8^+ T cells in the central nervous system at the onset of clinical signs of disease, while less than 2% of CD4^+ cells in the periphery expressed CD366 after immunization. RMT3-23 has been shown to have functional activity; blocks DC recognition of apoptotic cells and also induces autoantibody production. Applications Reported: This RMT3-23 antibody has been reported for use in flow cytometric analysis.
CD366 (TIM3) Monoclonal antibody specifically detects CD366 (TIM3) in Mouse samples. It is validated for Flow Cytometry.Specifications
CD366 (TIM3) | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3 | |
Havcr2 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Havcr2 |
RMT3-23 | |
Flow Cytometry | |
PE-Cyanine7 | |
Rat | |
Mouse | |
Q8VIM0 | |
171285 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.