CD366 (TIM3) Mouse, APC-eFluor 780, Clone: F38-2E2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 47-3109-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15519586

Quantity Price
1 £ 78.88 / 25 tests
EU Stock 1
Add to basket


Description and Specification

Specification

Antigen CD366 (TIM3)
Format Conjugated
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Isotype IgG1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Species Reactivity Human
Clone F38-2E2
Applications Flow Cytometry
Conjugate APC-eFluor 780
Concentration 5μL (0.125μg)/test
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias HAVCR2, T cell immunoglobulin and mucin domain-containing protein 3
Quantity 25 tests
Primary or Secondary Primary

This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2. This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g. Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells. Due to alternative splicing, CD366 exists as membrane-bound and soluble forms. Galectin-9 has been identified as the ligand for CD366. In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines. CD366 has also been implicated in tolerance, autoimmune disease (e.g. multiple sclerosis), and HIV infection.