CD366 (TIM3) Mouse anti-Human, eFluor 450, Clone: F38-2E2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-3109-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15579736

Quantity Price
1 £ 74.51 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Primary or Secondary Primary
Conjugate eFluor 450
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG1
Concentration 5μL (0.5μg)/test
Monoclonal or Polyclonal Monoclonal
Gene Alias HAVCR2, T cell immunoglobulin and mucin domain-containing protein 3
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Regulatory Status RUO
Format Conjugated
Clone F38-2E2
Quantity 25 tests
Host Species Mouse
Antigen CD366 (TIM3)

This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2. This cell surface receptor is expressed on activated CD4+ T cell subsets (e.g. Th1, Th17, and Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells. Due to alternative splicing, CD366 exists as membrane-bound and soluble forms. Galectin-9 has been identified as the ligand for CD366. In humans, this receptor negatively regulates CD4+ T cells, influencing the secretion of some Th1- and Th17-related cytokines. CD366 has also been implicated in tolerance, autoimmune disease (e.g. multiple sclerosis), and HIV infection.