missing translation for 'onlineSavingsMsg'
Learn More

CD363 (S1PR1), eFluor 660, clone: SW4GYPP, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-3639-41

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15559936

  • £95.25 / 25 tests


EU Stock 4
Add to basket

Description

Description

Description: The SW4GYPP monoclonal antibody recognizes human CD363, also known as sphingosine-1-phosphate receptor 1 (S1PR1, S1P1), or endothelial differentiation G-protein coupled receptor 1 (EDG1). CD363 is a part of a family of five G-protein-coupled receptors that bind sphingosine-1-phosphate (S1P), a lysophospholipid mediator. It has been shown to be primarily expressed by lymphocytes but is also seen on endothelial cells, B cells, NK cells, monocytes/macrophages, neural progenitors, neurons, astrocytes, and oligodendrocytes. CD363 surface expression is dependent on the extracellular concentration of S1P and its signaling is important for lymphocyte egress from secondary lymphoid tissues and the thymus. CD363 plays a key role in many cellular processes like angiogenesis, vascular maturation, endothelial barrier function and trafficking of immune cells. Therapeutic CD363 modulators have been successful in the treatment of relapsing-remitting multiple sclerosis through sequestration of immune cells in secondary lymphoid organs and, therefore, away from sites of inflammation.Applications Reported: This SW4GYPP antibody has been reported for use in flow cytometric analysis.Applications Tested: This SW4GYPP antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD363
Monoclonal
5μl/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P21453
Sphingolipid Receptor 1, Endothelial Differentiation Gene 1, EDG1, S1PR1
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
SW4GYPP
eFluor 660
S1PR1
Conjugated
S1PR1
IgG1, kappa
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
1901
Videos

For Research Use Only.