missing translation for 'onlineSavingsMsg'
Learn More

CD363 Mouse anti-Human, eFluor 660, Clone: SW4GYPP, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-3639-41

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15559936

  • £92.86 / 25 tests


EU Stock 5
Add to basket

Disclaimers:

For Research Use Only.


Specifications

Description

The SW4GYPP monoclonal antibody recognizes human CD363, also known as sphingosine-1-phosphate receptor 1 (S1PR1, S1P1), or endothelial differentiation G-protein coupled receptor 1 (EDG1). CD363 is a part of a family of five G-protein-coupled receptors that bind sphingosine-1-phosphate (S1P), a lysophospholipid mediator. It has been shown to be primarily expressed by lymphocytes but is also seen on endothelial cells, B cells, NK cells, monocytes/macrophages, neural progenitors, neurons, astrocytes, and oligodendrocytes. CD363 surface expression is dependent on the extracellular concentration of S1P and its signaling is important for lymphocyte egress from secondary lymphoid tissues and the thymus. CD363 plays a key role in many cellular processes like angiogenesis, vascular maturation, endothelial barrier function and trafficking of immune cells. Therapeutic CD363 modulators have been successful in the treatment of relapsing-remitting multiple sclerosis through sequestration of immune cells in secondary lymphoid organs and, therefore, away from sites of inflammation.
Description & Specifications

Specifications

CD363
SW4GYPP
eFluor 660
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.5μg)/test
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal