CD360 (IL-21 Receptor) Mouse anti-Human, PE, Clone: 2SX21R, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-3601-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15516976

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Regulatory Status RUO
Quantity 25 tests
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Isotype IgG1
Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 2SX21R
Antigen CD360 (IL-21 Receptor)
Conjugate PE
Format Conjugated
Primary or Secondary Primary

This 2SX21R monoclonal antibody reacts with human CD360 (Interleukin-21 Receptor, IL-21R). IL-21R forms a heterodimeric receptor complex with the common gamma chain to form a functional receptor for IL-21. IL-21 is a class I cytokine of the common gamma chain family of cytokines and signals through the IL-21R complex to activate the JAK/STAT (Janus Kinase/Signal Transducers and Activators of Transcription) signaling pathway. Activation of the JAK/STAT pathway by IL-21 promotes transcription of genes responsive to STAT1 and STAT3. IL-21 is mainly produced by CD4+ T cells and mediates the proliferation, differentiation, and effector functions of cells expressing IL-21R such as B cells, T cells, NK cells, dendritic cells and other populations of myeloid cells. IL-21 and its receptor are implicated in the pathogenesis of chronic viral infections, autoimmunity, allergy, organ transplantation, and cancer.