CD357 (GITR) Rat anti-Mouse, PerCP-eFluor 710, Clone: DTA-1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-5874-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15599286

Quantity Price
1 £ 205.47 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Species Reactivity Mouse
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Quantity 100μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG2b
Antigen CD357 (GITR)
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Concentration 0.2mg/mL
Clone DTA-1
Applications Flow Cytometry

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.