CD357 (AITR/GITR), PE-Cyanine7, clone: DTA-1, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 25-5874-80
Code : Z2
Additional Details : Weight : 0.25000kg
DescriptionThe DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.
|Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage, handling and experimental procedures.|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|TNFRSF18, AITR, glucocorticoid-induced TNFR-related|
For Research Use Only.