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CD357 (GITR) Rat anti-Mouse, FITC, Clone: DTA-1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-5874-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15278269

  • £66.65 / 25µg


Estimated Shipment date
from Supplier 28-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.
Specifications

Specifications

CD357
DTA-1
FITC
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TNFRSF18, AITR, glucocorticoid-induced TNFR-related
IgG2b
RUO
Primary
Murine