CD357 (GITR) Rat anti-Mouse, eFluor 450, Clone: DTA-1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-5874-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15301800

Quantity Price
1 £ 174.09 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD357 (GITR)
Concentration 0.2mg/mL
Quantity 100μg
Applications Flow Cytometry
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Host Species Rat
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Mouse
Isotype IgG2b
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Clone DTA-1
Primary or Secondary Primary

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.