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CD357 (GITR) Rat anti-Mouse, Clone: DTA-1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-5874-83

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15238667

  • £231.74 / 200µg


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For Research Use Only.


Description

Description

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.
Specifications

Specifications

CD357 (GITR)
DTA-1
Unconjugated
Purified
Rat
200μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
TNFRSF18, AITR, glucocorticoid-induced TNFR-related
IgG2b
RUO
Primary
Murine
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