CD357 (GITR) Rat anti-Mouse, Clone: DTA-1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5874-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228667

Quantity Price
1 £ 84.99 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
Add to basket


Description and Specification

Specification

Concentration 1mg/mL
Applications Flow Cytometry
Applications Functional Assay
Monoclonal or Polyclonal Monoclonal
Format Purified
Primary or Secondary Primary
Isotype IgG2b
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO
Quantity 50μg
Species Reactivity Mouse
Host Species Rat
Gene Alias TNFRSF18, AITR, glucocorticoid-induced TNFR-related
Conjugate Unlabeled
Clone DTA-1
Storage Requirements Store at 2-8°C.
Antigen CD357 (GITR)

The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.