CD357 (AITR/GITR) Mouse anti-Human, PerCP-eFluor 710, Clone: eBioAITR, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-5875-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15509296

Quantity Price
1 £ 83.43 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Applications Flow Cytometry
Regulatory Status RUO
Antigen CD357 (AITR/GITR)
Format Conjugated
Clone eBioAITR
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias TNFRSF18, activation-inducible TNFR family member
Conjugate PerCP-eFluor 710
Primary or Secondary Primary
Isotype IgG1
Concentration 5μL (0.25μg)/test
Quantity 25 tests
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Human
Host Species Mouse

The monoclonal antibody reacts with human AITR, Activation Inducible TNFR family member, an approximately 25kDa member of the TNFR superfamily. AITR mRNA is detected in lymph node, peripheral blood leukocytes and weakly in spleen. AITR mRNA expression was upregulated within 24 hour on PMA/ionomycin or PHA stimulated PBMC. At the protein level, AITR is expressed by a small population of activated PBMC. AITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-kappaB activation via TRAF2. Recently TL6 (AITRL) has been reported as the ligand for AITR. Interaction of AITR with AITRL is important for cross-talk between T lymphocytes and endothelial cells.