CD357 (AITR/GITR) Mouse anti-Human, PE-Cy7, Clone: eBioAITR, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 25-5875-42

100TEST Anti-Human CD357 (AITR/GITR) PE-Cyanine7

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15538586

Quantity Price
1 £ 306.5 / 100 tests
Estimated Shipment date
from Supplier 20-01-2017
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Description and Specification

Specification

Antigen CD357 (AITR/GITR)
Applications Flow Cytometry
Clone eBioAITR
Concentration 5μL (1.0μg)/test
Conjugate PE-Cy7
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias TNFRSF18, activation-inducible TNFR family member
Host Species Mouse
Isotype IgG1
Quantity 100 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody reacts with human AITR, Activation Inducible TNFR family member, an approximately 25kDa member of the TNFR superfamily. AITR mRNA is detected in lymph node, peripheral blood leukocytes and weakly in spleen. AITR mRNA expression was upregulated within 24 hour on PMA/ionomycin or PHA stimulated PBMC. At the protein level, AITR is expressed by a small population of activated PBMC. AITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-kappaB activation via TRAF2. Recently TL6 (AITRL) has been reported as the ligand for AITR. Interaction of AITR with AITRL is important for cross-talk between T lymphocytes and endothelial cells.