CD357 (AITR/GITR) Mouse anti-Human, Alexa Fluor 488, Clone: eBioAITR, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-5875-41

UNSPSC: 12000000

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 12672069

Quantity Price
1 £ 129.54 / Each
EU Stock 4
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Description and Specification

Specification

Host Species Murine
Quantity 25 Tests
Antigen CD357 (AITR/GITR)
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Gene Alias TNFRSF18, activation-inducible TNFR family member
Concentration 5μL (0.25μg)/test
Conjugate Alexa Fluor 488
Clone eBioAITR
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Applications Flow Cytometry
Primary or Secondary Primary
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG1

The monoclonal antibody reacts with human AITR, Activation Inducible TNFR family member, an approximately 25kDa member of the TNFR superfamily. AITR mRNA is detected in lymph node, peripheral blood leukocytes and weakly in spleen. AITR mRNA expression was upregulated within 24 hour on PMA/ionomycin or PHA stimulated PBMC. At the protein level, AITR is expressed by a small population of activated PBMC. AITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-κB activation via TRAF2. Recently TL6 (AITRL) has been reported as the ligand for AITR. Interaction of AITR with AITRL is important for cross-talk between T lymphocytes and endothelial cells.