CD34 Mouse anti-Human, PerCP-eFluor 710, Clone: 4H11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-0349-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15579106

Quantity Price
1 £ 96.09 / 25 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Quantity 25 tests
Applications Flow Cytometry
Antigen CD34
Regulatory Status RUO
Isotype IgG1
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Mucosialin, Class III epitope
Concentration 5μL (0.125μg)/test
Conjugate PerCP-eFluor 710
Species Reactivity Human
Format Conjugated
Host Species Mouse
Clone 4H11
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.