CD34 Mouse anti-Human, PE, Clone: 4H11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-0349-41

UNSPSC: 12000000

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 12621949

Quantity Price
1 £ 67.24 / Each
EU Stock 4
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Description and Specification

Specification

Quantity 25 Tests
Host Species Murine
Isotype IgG1
Conjugate PE
Antigen CD34
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 4H11
Primary or Secondary Primary
Applications Flow Cytometry
Regulatory Status RUO
Concentration 5μL (0.5μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Species Reactivity Human
Gene Alias Mucosialin, Class III epitope

The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.