CD34 Mouse anti-Human, Clone: 4H11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0349-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15236917

Quantity Price
1 £ 66.65 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Host Species Mouse
Concentration 0.5mg/mL
Format Purified
Quantity 100μg
Applications Flow Cytometry
Applications Functional Assay
Applications Western Blotting
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Antigen CD34
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Species Reactivity Human
Clone 4H11
Gene Alias Mucosialin, Class III epitope

The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.