CD336 (NKp44) Mouse anti-Human, PE, Clone: 44.189, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-3369-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15576966

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Applications Flow Cytometry
Primary or Secondary Primary
Quantity 25 tests
Antigen CD336 (NKp44)
Host Species Mouse
Concentration 5μL (0.125μg)/test
Regulatory Status RUO
Gene Alias NCR2
Isotype IgG2b
Format Conjugated
Conjugate PE
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Clone 44.189
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody 44.189 reacts with human CD336, which is also known as NKp44 or NCR2. CD336 is a 44kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein. Once thought to be expressed exclusively on IL-2-activated NK cells and a subset of gamma delta T lymphocytes, studies have shown expression of CD336 on IL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 has been shown to be involved in the innate response of activated NK cells against viral infection and tumor cell proliferation.

The 44.189 antibody has been reported to facilitate CD336 crosslinking.