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CD335 (NKp46) Rat anti-Mouse, PE-eFluor 610, Clone: 29A1.4, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 61-3351-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15560487

  • £74.51 / 25µg


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For Research Use Only.


Description

Description

The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines.

The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.
Specifications

Specifications

CD335 (NKp46)
29A1.4
PE-eFluor™ 610
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
NCR1, Ly-94
IgG2a
RUO
Primary
Murine
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