CD335 (NKp46) Rat anti-Mouse, FITC, Clone: 29A1.4, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-3351-82

100ug Anti-Mouse CD335 (NKp46) FITC

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 1.00000kg



Disclaimers: For Research Use Only.

Product Code. 15202008

Quantity Price
1 £ 176.0 / 100µg
Estimated Shipment date
from Supplier 22-02-2017
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Description and Specification

Specification

Antigen CD335 (NKp46)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias NCR1, Ly-94
Host Species Rat
Applications Flow Cytometry
Quantity 100μg
Regulatory Status RUO
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Conjugate FITC
Format Conjugated
Isotype IgG2a
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 29A1.4
Concentration 0.5mg/mL

The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines.

The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.