CD335 (NKp46) Rat anti-Mouse, Clone: 29A1.4, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-3351-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278607

Quantity Price
1 £ 225.61 / 500µg
EU Stock 6
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Description and Specification

Specification

Format Purified
Quantity 500μg
Primary or Secondary Primary
Isotype IgG2a
Antigen CD335 (NKp46)
Gene Alias NCR1, Ly-94
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Functional Assay
Storage Requirements Store at 2-8°C.
Concentration 1mg/mL
Conjugate Unlabeled
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO
Host Species Rat
Clone 29A1.4
Species Reactivity Mouse

The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines.

The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.