CD335 (NKp46) Rat anti-Mouse, Clone: 29A1.4, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-3351-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268607

Quantity Price
1 £ 91.11 / 50µg
EU Stock 1
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Description and Specification

Specification

Gene Alias NCR1, Ly-94
Clone 29A1.4
Formulation aqueous buffer, no sodium azide
Host Species Rat
Applications Flow Cytometry
Applications Functional Assay
Storage Requirements Store at 2-8°C.
Species Reactivity Mouse
Concentration 1mg/mL
Antigen CD335 (NKp46)
Conjugate Unlabeled
Format Purified
Regulatory Status RUO
Isotype IgG2a
Quantity 50μg
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines.

The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.