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CD335 (NKp46) Rat anti-Mouse, Clone: 29A1.4, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-3351-81

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15268607

  • £91.11 / 50µg


EU Stock 1
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines.

The 29A1.4 monoclonal antibody has been shown to activate NK cells in vitro. The 29A1.4 monoclonal antibody does not deplete NK cells in vivo.
Description & Specifications

Specifications

CD335 (NKp46)
29A1.4
Unlabeled
aqueous buffer, no sodium azide
Rat
50μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
Purified
NCR1, Ly-94
IgG2a
RUO
Primary
Murine