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CD33 Monoclonal Antibody (P67.6), FITC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£63.00 - £150.00

Specifications

Antigen CD33
Clone P67.6
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15586376
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Affymetrix eBioscience
11-0337-42
100 Tests
£150.00
100 tests
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15576376
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Affymetrix eBioscience
11-0337-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

Description: The P67.6 monoclonal antibody reacts with human CD33 (also known as GP67 and P67), a 67 kDa type I transmembrane glycoprotein that is a member of the Siglec (sialic acid-binding Ig superfamily lectin) family. It is highly specific to the hematopoietic compartment and is expressed on monocytes, activated T cells, granulocytes, myeloid progenitors, and mast cells. Applications Reported: This P67.6 antibody has been reported for use in flow cytometric analysis. Applications Tested: This P67.6 antibody has been pre-titrated and tested by flow cytometric analysis of lysed whole blood. This can be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
Specifications

Specifications

CD33
5 μL/Test
Monoclonal
Liquid
RUO
P20138
CD33
Primary
4° C, store in dark, DO NOT FREEZE!
CD33
P67.6
Flow Cytometry
FITC
Mouse
Human
945
IgG1 κ
Affinity chromatography
Antibody
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