CD326 (EpCAM) Rat anti-Mouse, eFluor 450, Clone: G8.8, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-5791-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15351790

Quantity Price
1 £ 176.7 / 100µg
EU Stock 3
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Description and Specification

Specification

Gene Alias epithelial cell adhesion molecule
Isotype IgG2a
Conjugate eFluor 450
Species Reactivity Mouse
Applications Flow Cytometry
Antigen CD326 (EpCAM)
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Primary or Secondary Primary
Clone G8.8
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 0.2mg/mL
Host Species Rat
Quantity 100μg
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The G8.8 monoclonal antibody reacts with the 40kDa protein mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. The immunogen used to generate the G8.8 antibody was the TE-71 thymic epithelial cell line. CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. The antigen is being used as a target for immunotherapy treatment of human carcinomas. CD326 binds LAIR-1 (CD305) and LAIR-2 (CD306) to inhibit cellular activation and inflammation. This epithelial glycoprotein is now recognized as having an important role in tumor biology.