CD325 (N-cadherin) Mouse anti-Human, PE, Clone: 8C11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-3259-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15556966

Quantity Price
1 £ 66.65 / 25 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Species Reactivity Human
Applications Flow Cytometry
Format Conjugated
Conjugate PE
Clone 8C11
Primary or Secondary Primary
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Gene Alias neural cadherin
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 25 tests
Concentration 5μL (0.25μg)/test
Antigen CD325 (N-cadherin)

The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.