CD325 (N-cadherin) Mouse anti-Human, Clone: 8C11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-3259-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15217347

Quantity Price
1 £ 72.77 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Immunohistochemistry
Applications Immunoprecipitation
Applications Western Blotting
Gene Alias neural cadherin
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Host Species Mouse
Quantity 100μg
Concentration 0.5mg/mL
Species Reactivity Human
Conjugate Unlabeled
Primary or Secondary Primary
Clone 8C11
Antigen CD325 (N-cadherin)
Format Purified

The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.