CD325 (N-cadherin) Mouse anti-Human, Biotin, Clone: 8C11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-3259-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15259789

Quantity Price
1 £ 274.53 / 500µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Host Species Mouse
Species Reactivity Human
Isotype IgG1
Format Conjugated
Clone 8C11
Quantity 500μg
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze.
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Biotin
Gene Alias neural cadherin
Applications Flow Cytometry
Antigen CD325 (N-cadherin)

The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.